Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 5/20 | 0.36 |
| ▸ | PIM1 | P11309 | 6/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 5/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.30 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167429 | 0.85 | MET (0.43) | METPDE10A | |
| SCHEMBL21167483 | 0.81 | MET (0.36) | METPIM1PIM3PIM2PDE10A | |
| SCHEMBL22475826 | 0.73 | MET (0.52) | METPDE10A | |
| SCHEMBL21167772 | 0.71 | MET (0.54) | METPDE10A | |
| SCHEMBL21167613 | 0.71 | MET (0.53) | METPDE10A | |
| SCHEMBL21167428 | 0.70 | MET (0.44) | METPDE10A | |
| SCHEMBL24591038 | 0.70 | MET (0.44) | METPDE10A | |
| SCHEMBL24591060 | 0.70 | MET (0.41) | METPDE10A | |
| SCHEMBL23127970 | 0.69 | MET (0.37) | METPDE10AJAK2JAK1TYK2 | |
| SCHEMBL21167471 | 0.69 | MET (0.42) | METPDE10AJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |