Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 10/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 10/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 8/20 | 0.33 |
| ▸ | KDR | P35968 | 8/20 | 0.33 |
| ▸ | FLT3 | P36888 | 4/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.32 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.32 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 2/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22475785 | 0.88 | MET (0.56) | METFGFR1FGFR2FGFR3MAPK1 | |
| SCHEMBL21167774 | 0.87 | MET (0.45) | METFGFR1FGFR2FGFR3MAPK1 | |
| SCHEMBL21167343 | 0.83 | MET (0.44) | METKDR | |
| SCHEMBL21167577 | 0.78 | MET (0.52) | METPIM1CSF1R | |
| SCHEMBL12689725 | 0.74 | MET (0.79) | MET | |
| SCHEMBL21167378 | 0.73 | MET (0.40) | METPIM1 | |
| SCHEMBL24590984 | 0.69 | MET (0.56) | METFGFR1FGFR2FGFR3MAPK1 | |
| SCHEMBL21167712 | 0.68 | MET (0.43) | METFGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL21167339 | 0.65 | MET (0.43) | METFGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL12487421 | 0.64 | MET (0.41) | METFGFR1FGFR2FGFR3FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |