Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.45 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167343 | 0.90 | MET (0.44) | METJAK2JAK1TYK2JAK3 | |
| SCHEMBL22475785 | 0.89 | MET (0.56) | METMAPK1MAPTFGFR1FGFR2 | |
| SCHEMBL21167541 | 0.87 | MET (0.44) | METMAPK1PIM1SYKFGFR1 | |
| SCHEMBL21167378 | 0.79 | MET (0.40) | METPIM1JAK2JAK1TYK2 | |
| SCHEMBL21167577 | 0.78 | MET (0.52) | METPIM1MAPTCSF1R | |
| SCHEMBL23127940 | 0.74 | ATR (0.41) | METATRMAPK1PIM1LRRK2 | |
| SCHEMBL12489807 | 0.73 | MET (0.80) | MET | |
| SCHEMBL21167339 | 0.71 | MET (0.43) | METJAK2JAK1TYK2JAK3 | |
| SCHEMBL24590984 | 0.70 | MET (0.56) | METMAPK1FGFR1FGFR2FGFR4 | |
| SCHEMBL22109430 | 0.69 | MET (0.45) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |