Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 3/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | LDHB | P07195 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 4/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.37 |
| ▸ | KDR | P35968 | 5/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22475890 | 0.85 | MET (0.43) | CSF1RMETLDHALDHBSYK | |
| SCHEMBL23127845 | 0.85 | MET (0.43) | CSF1RMETLDHALDHBSYK | |
| SCHEMBL21167664 | 0.84 | EGFR (0.40) | METEGFRIKBKETBK1FGFR1 | |
| SCHEMBL21167564 | 0.81 | MET (0.59) | CSF1RMETLDHALDHBEGFR | |
| SCHEMBL16882496 | 0.79 | MET (0.45) | METSYKFGFR1FGFR3KDR | |
| SCHEMBL12689736 | 0.78 | MET (0.66) | MET | |
| SCHEMBL22475682 | 0.78 | MET (0.42) | METSYKFGFR1FGFR3KDR | |
| SCHEMBL24591095 | 0.78 | MET (0.40) | METSYKFGFR1FGFR3KDR | |
| SCHEMBL21167473 | 0.75 | MET (0.47) | CSF1RMETLDHALDHBSYK | |
| SCHEMBL23127964 | 0.75 | CSF1R (0.50) | CSF1RMETLDHALDHBSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |