Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 9/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.35 |
| ▸ | KDR | P35968 | 5/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24591054 | 0.87 | MET (0.57) | METMAP4K4FGFR1FGFR2FGFR4 | |
| SCHEMBL21167403 | 0.80 | MET (0.56) | METFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL24591049 | 0.78 | MET (0.41) | METMAP4K4FGFR1FGFR2FGFR4 | |
| SCHEMBL21167750 | 0.77 | MET (0.40) | METFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL21167475 | 0.76 | MET (0.45) | METFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL24591124 | 0.74 | MET (0.46) | METFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL24591013 | 0.74 | MET (0.57) | MET | |
| SCHEMBL12487188 | 0.74 | MET (0.54) | METFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL22475951 | 0.73 | CSF1R (0.58) | METKITFGFR1FGFR2FGFR3 | |
| SCHEMBL21167564 | 0.73 | MET (0.59) | METKITBRD4PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |