Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167389 | 0.90 | PIM1 (0.43) | METPIM1 | |
| SCHEMBL24590996 | 0.90 | MET (0.41) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL21167329 | 0.85 | MET (0.67) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL12487158 | 0.80 | MET (0.75) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL19261423 | 0.79 | MET (0.65) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL24591084 | 0.78 | PIM1 (0.43) | PIM1 | |
| SCHEMBL16882514 | 0.78 | MET (0.52) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL12489725 | 0.76 | MET (0.58) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL24591016 | 0.76 | MET (0.47) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL21167683 | 0.76 | MET (0.47) | METPDE3BPDE3ACYP2C9PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |