Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 13/20 | 0.67 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.41 |
| ▸ | CDK2 | P24941 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24591029 | 0.85 | MET (0.63) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL21167682 | 0.85 | MET (0.51) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL12693351 | 0.80 | MET (1.00) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL19261423 | 0.78 | MET (0.65) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL16882514 | 0.77 | MET (0.52) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL12489241 | 0.77 | MET (0.79) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL24591031 | 0.76 | MET (0.61) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL22475809 | 0.75 | MET (0.60) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL24590996 | 0.75 | MET (0.41) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL24591016 | 0.75 | MET (0.47) | METPDE3BPDE3ACYP2C9PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |