Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 7/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 7/20 | 0.36 |
| ▸ | KDR | P35968 | 6/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 4/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167759 | 0.87 | DYRK1A (0.40) | METFGFR1FGFR3KDRFGFR2 | |
| SCHEMBL21167772 | 0.84 | MET (0.54) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL21171421 | 0.81 | SCD (0.38) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL21167471 | 0.78 | MET (0.42) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL23127970 | 0.76 | MET (0.37) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL12482410 | 0.76 | MET (0.56) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL21167378 | 0.76 | MET (0.40) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL21167613 | 0.75 | MET (0.53) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL21167770 | 0.75 | CYP2A6 (0.41) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL14378441 | 0.73 | MET (0.59) | METCYP2C9PDE3BPDE3APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3795573-A1 | CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRIDINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | Hutchison Medipharma Limited (CN) | 2021-03-24 | — | — | EP | disclosed |
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |