Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 3/20 | 0.41 |
| ▸ | MET | P08581 | 6/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24590989 | 0.89 | MET (0.43) | CYP2A6METIKBKETBK1FGFR1 | |
| SCHEMBL21167471 | 0.85 | MET (0.42) | METFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL23127908 | 0.81 | CYP2A6 (0.42) | CYP2A6METIKBKETBK1MAPT | |
| SCHEMBL22475975 | 0.78 | MET (0.43) | CYP2A6METIKBKETBK1FGFR1 | |
| SCHEMBL21171421 | 0.75 | SCD (0.38) | METMAPTFGFR1FGFR2FGFR4 | |
| SCHEMBL21167772 | 0.75 | MET (0.54) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL22475678 | 0.75 | CYP2A6 (0.41) | CYP2A6METIKBKETBK1MAPT | |
| SCHEMBL21167701 | 0.75 | MET (0.37) | METFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL23127970 | 0.74 | MET (0.37) | METFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL16882505 | 0.73 | MET (0.43) | CYP2A6METMAPTJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |