Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.55 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167532 | 1.00 | MET (0.55) | METPDE3BPDE3APDE4CPDE4D | |
| SCHEMBL21167772 | 0.82 | MET (0.54) | METPDE3BPDE3APDE4CPDE4D | |
| SCHEMBL22475985 | 0.79 | MET (0.46) | METPDE3BPDE3APDE4CPDE4D | |
| SCHEMBL21167399 | 0.78 | MET (0.47) | METPDE3BPDE3APDE4CPDE4D | |
| SCHEMBL29314852 | 0.77 | MET (0.45) | METPDE3BPDE3APDE4CPDE4D | |
| SCHEMBL21167471 | 0.76 | MET (0.42) | METPDE3BPDE3APDE4CPDE4D | |
| SCHEMBL1329580 | 0.76 | MET (0.81) | METPDE3BPDE3APDE4CPDE4D | |
| SCHEMBL12489756 | 0.76 | MET (0.81) | METPDE3BPDE3APDE4CPDE4D | |
| SCHEMBL12489793 | 0.76 | MET (0.81) | METPDE3BPDE3APDE4CPDE4D | |
| SCHEMBL21167613 | 0.75 | MET (0.53) | METPDE3BPDE3APDE10ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |