SCHEMBL21167775

SCHEMBL21167775

N#Cc1ccc(-c2cnc(N)c(NCc3ccc4nccn4c3)n2)cn1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MET P08581 3/20 0.57
TRIM33 Q9UPN9 3/20 0.43
HDAC1 Q13547 1/20 0.40
LDHA P00338 1/20 0.39
LDHB P07195 1/20 0.39
KEAP1 Q14145 1/20 0.39
CSF1R P07333 1/20 0.37
DYRK1A Q13627 1/20 0.36
NAMPT P43490 2/20 0.36
PAK1 Q13153 1/20 0.35
EPHB4 P54760 1/20 0.34
RET P07949 1/20 0.34
PDE4A P27815 1/20 0.34
PDE4B Q07343 1/20 0.34
PDE4C Q08493 1/20 0.34
PDE4D Q08499 1/20 0.34
AXL P30530 1/20 0.34
FLT3 P36888 1/20 0.34
MERTK Q12866 1/20 0.34
ATR Q13535 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21167452 0.83 MET (0.54) METTRIM33LDHALDHBKEAP1
SCHEMBL21167380 0.83 DYRK1A (0.44) METTRIM33LDHALDHBKEAP1
SCHEMBL21167509 0.83 NAMPT (0.42) METTRIM33HDAC1LDHALDHB
SCHEMBL21167350 0.83 TRIM33 (0.42) METTRIM33LDHALDHBKEAP1
SCHEMBL22475927 0.81 MET (0.43) METTRIM33LDHALDHBKEAP1
SCHEMBL21167421 0.80 CSF1R (0.59) METLDHALDHBKEAP1CSF1R
SCHEMBL24591023 0.79 MET (0.53) METTRIM33KEAP1AXLFLT3
SCHEMBL22475658 0.78 CSF1R (0.46) METTRIM33LDHALDHBKEAP1
SCHEMBL21167458 0.77 LDHA (0.43) METHDAC1LDHALDHBCSF1R
SCHEMBL21167673 0.77 CSF1R (0.45) METTRIM33LDHALDHBKEAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3795573-B1 CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR HUTCHISON MEDIPHARMA LTD (CN) 2022-07-06 EP disclosed
EP-3795573-A1 CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRIDINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR Hutchison Medipharma Limited (CN) 2021-03-24 EP disclosed
EP-3511330-B1 SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS HUTCHISON MEDIPHARMA LTD (CN) 2020-09-30 EP disclosed
EP-3511330-A1 SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS Hutchison Medipharma Limited (CN) 2019-07-17 EP disclosed