Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 6/20 | 0.62 |
| ▸ | LDHB | P07195 | 8/20 | 0.44 |
| ▸ | LDHA | P00338 | 8/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167599 | 0.91 | MET (0.60) | METPDE4CPDE4DPDE3BPDE3A | |
| SCHEMBL22475690 | 0.88 | MET (0.59) | METPDE4CPDE4DPDE3BPDE3A | |
| SCHEMBL21167779 | 0.88 | MET (0.59) | METPDE4CPDE4DPDE3BPDE3A | |
| SCHEMBL24591159 | 0.88 | MET (0.59) | METPDE4CPDE4DPDE3BPDE3A | |
| SCHEMBL21167564 | 0.83 | MET (0.59) | METLDHBLDHAPDE4CPDE4D | |
| SCHEMBL22475914 | 0.81 | LDHB (0.42) | METLDHBLDHAPDE4CPDE4D | |
| SCHEMBL21167600 | 0.78 | MET (0.55) | METPDE4CPDE4DPDE3BPDE3A | |
| SCHEMBL12690039 | 0.77 | MET (1.00) | METPDE4CPDE4DPDE3BPDE3A | |
| SCHEMBL12489803 | 0.77 | MET (1.00) | METPDE4CPDE4DPDE3BPDE3A | |
| SCHEMBL17425917 | 0.77 | MET (0.63) | METPDE4CPDE4DPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |