Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2116889 | 0.86 | BCHE (0.34) | CHRNB2CHRNB4CHRNA3CHRNA4BCHE | |
| SCHEMBL2116802 | 0.86 | CHRNB2 (0.34) | CHRNB2CHRNB4CHRNA3CHRNA4BCHE | |
| SCHEMBL2116336 | 0.82 | BCHE (0.37) | BCHEACHEMAOB | |
| SCHEMBL2117313 | 0.82 | CHRNB2 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4BCHE | |
| SCHEMBL2116532 | 0.77 | ACHE (0.39) | CHRNB2CHRNB4CHRNA3CHRNA4BCHE | |
| SCHEMBL2118658 | 0.77 | NPC1 (0.39) | CHRNB2CHRNB4CHRNA3CHRNA4BCHE | |
| SCHEMBL2116431 | 0.75 | BCHE (0.39) | CHRNB2CHRNB4CHRNA3CHRNA4BCHE | |
| SCHEMBL24556397 | 0.74 | BCHE (0.40) | CHRNB2CHRNB4CHRNA3CHRNA4BCHE | |
| SCHEMBL2115839 | 0.72 | BCHE (0.36) | BCHEKDM4EALDH1A1ACHEMAOB | |
| SCHEMBL2116800 | 0.71 | BCHE (0.34) | CHRNB2CHRNB4CHRNA3CHRNA4BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158652-B2 | 1-Difluoromethyl-5-{4-[3-(1-piperidinyl)propoxy]phenyl}-2(1H)-pyridone; compounds act as histamine-H3 receptor antagonistic substances or inverse-agonistic substances; useful as preventives or remedies for various circular system diseases, nervous system diseases, metabolic system diseases | MSD K.K. (JP) | 2012-04-17 | — | — | US | disclosed |
| US-20080269287-A1 | Substituted Pyridone Derivative | MSD K.K. (JP) | 2008-10-30 | — | — | US | disclosed |
| EP-1820797-A1 | SUBSTITUTED PYRIDONE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-08-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269287-A1 | Substituted Pyridone Derivative | HRH3, HRH4, HRH1 | CHRNB2 2027/4885CHRNB4 1011/4885CHRNA3 780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.