Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | LDHB | P07195 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12287289 | 0.85 | DPP4 (0.42) | DPP4MAPK14PARP1FYNCLK1 | |
| SCHEMBL12287723 | 0.85 | DPP4 (0.42) | DPP4MAPK14PARP1FYNCLK1 | |
| SCHEMBL21170038 | 0.85 | DPP4 (0.42) | DPP4MAPK14PARP1FYNCLK1 | |
| SCHEMBL21170168 | 0.81 | DPP4 (0.41) | DPP4MAPK14PARP1FYNCLK1 | |
| SCHEMBL2558433 | 0.80 | KDR (0.44) | DHODHMAPK14PARP1MAP2K4CLK1 | |
| SCHEMBL21170045 | 0.80 | PTGDR2 (0.43) | MAPK14KDRPTGDR2PSEN1PSEN2 | |
| SCHEMBL12295523 | 0.80 | DPP4 (0.48) | DPP4PARP1FYNCLK1LDHB | |
| SCHEMBL12295515 | 0.80 | DPP4 (0.48) | DPP4PARP1FYNCLK1LDHB | |
| SCHEMBL19422102 | 0.78 | FYN (0.40) | DHODHPARP1MAP3K5FYNMAP2K4 | |
| SCHEMBL19422104 | 0.78 | FYN (0.40) | DHODHPARP1MAP3K5FYNMAP2K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |