Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170143 | 0.83 | GABRG2 (0.43) | PTGDR2GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL21170044 | 0.80 | DPP4 (0.40) | PTGDR2MAPK14PSEN1PSEN2APH1B | |
| SCHEMBL12287314 | 0.80 | TRPA1 (0.42) | PTGDR2GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL21170333 | 0.80 | GABRG2 (0.44) | PTGDR2GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL21170118 | 0.72 | NPY5R (0.40) | NPY5R | |
| SCHEMBL12287988 | 0.69 | KCNH2 (0.44) | GABRG2GABRB3GABRA5GABRA3ADORA2A | |
| SCHEMBL11625379 | 0.67 | CLK4 (0.45) | GABRG2GABRB3GABRA5GABRA3TRPA1 | |
| SCHEMBL11634822 | 0.67 | ADORA2A (0.41) | PTGDR2GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL11628595 | 0.67 | ADORA2A (0.44) | GABRG2GABRB3GABRA5GABRA3ADORA2A | |
| SCHEMBL14734692 | 0.66 | GABRG2 (0.36) | GABRG2GABRB3GABRA5GABRA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |