Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | LDHB | P07195 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12287723 | 1.00 | DPP4 (0.42) | DPP4HPGDSFYNLDHBCLK1 | |
| SCHEMBL12287289 | 1.00 | DPP4 (0.42) | DPP4HPGDSFYNLDHBCLK1 | |
| SCHEMBL21170446 | 0.91 | HPGDS (0.44) | DPP4HPGDSFYNLDHBPARP1 | |
| SCHEMBL19422102 | 0.91 | FYN (0.40) | FYNLDHBPARP1PIK3CAMAPK8 | |
| SCHEMBL19422104 | 0.91 | FYN (0.40) | FYNLDHBPARP1PIK3CAMAPK8 | |
| SCHEMBL12286690 | 0.90 | LDHB (0.47) | FYNLDHBPARP1PIK3CAMAPK8 | |
| SCHEMBL21170136 | 0.90 | LDHB (0.43) | FYNLDHBPARP1MEN1KMT2A | |
| SCHEMBL21170185 | 0.89 | TRPM8 (0.41) | LDHBTRPM8MEN1NPC1ALDH1A1 | |
| SCHEMBL21170091 | 0.89 | MAP4K4 (0.38) | FYNTRPM8MEN1NPC1ALDH1A1 | |
| SCHEMBL21170314 | 0.88 | NPC1 (0.41) | DPP4CLK1MEN1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |