Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | IL1B | P01584 | 7/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 3/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170134 | 0.89 | PSEN1 (0.37) | NPC1RAB9AIL1BTNF | |
| SCHEMBL21170239 | 0.86 | PSEN1 (0.33) | NPC1USP2TP53RAB9ASMN1; SMN2 | |
| SCHEMBL21170358 | 0.83 | PSEN1 (0.39) | NPC1RAB9AIL1BTNF | |
| SCHEMBL21170238 | 0.80 | PSEN1 (0.37) | NPC1RAB9AIL1BTNF | |
| SCHEMBL12289929 | 0.77 | KCNA5 (0.39) | NPC1USP2TP53RAB9ASMN1; SMN2 | |
| SCHEMBL21170112 | 0.74 | PSEN1 (0.35) | NPC1RAB9AIL1BTNF | |
| SCHEMBL21170490 | 0.74 | SLC6A2 (0.38) | NPC1RAB9AIL1BTNF | |
| SCHEMBL21170473 | 0.74 | PSEN1 (0.35) | NPC1RAB9AIL1BTNF | |
| SCHEMBL12287901 | 0.72 | NPC1 (0.45) | NPC1USP2TP53RAB9ASMN1; SMN2 | |
| SCHEMBL21170341 | 0.70 | IL1B (0.39) | NPC1USP2TP53RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |