Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.61 |
| ▸ | DRD1 | P21728 | 1/20 | 0.61 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.61 |
| ▸ | DRD3 | P35462 | 1/20 | 0.61 |
| ▸ | CASR | P41180 | 1/20 | 0.61 |
| ▸ | HTR2B | P41595 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2117373 | 1.00 | LMNA (0.61) | LMNACYP3A4CHRM2HTR1AADRA2A | |
| SCHEMBL11421702 | 1.00 | LMNA (0.61) | LMNACYP3A4CHRM2HTR1AADRA2A | |
| SCHEMBL28205381 | 0.94 | RRM1 (0.59) | LMNACYP3A4CHRM2HTR1AADRA2A | |
| SCHEMBL4800277 | 0.88 | CYP3A4 (0.66) | LMNACYP3A4CHRM2HTR1AADRA2A | |
| SCHEMBL3158749 | 0.88 | CYP3A4 (0.66) | LMNACYP3A4CHRM2HTR1AADRA2A | |
| SCHEMBL5499560 | 0.88 | CYP3A4 (0.66) | LMNACYP3A4CHRM2HTR1AADRA2A | |
| SCHEMBL1101513 | 0.88 | CYP3A4 (0.70) | LMNACYP3A4CHRM2HTR1AADRA2A | |
| SCHEMBL5461331 | 0.88 | CYP3A4 (0.70) | LMNACYP3A4CHRM2HTR1AADRA2A | |
| SCHEMBL10779809 | 0.88 | CYP3A4 (0.70) | LMNACYP3A4CHRM2HTR1AADRA2A | |
| Bromide SCHEMBL7257777 | 0.86 | CYP3A4 (0.63) | LMNACYP3A4CHRM2HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9108957-B2 | 3-[1,4]oxazepane-4-pyrimidone derivatives | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2015-08-18 | — | — | US | disclosed |
| US-20120095216-A1 | 3-[1,4]OXAZEPANE-4-PYRIMIDONE DERIVATIVES | SANOFI (FR) | 2012-04-19 | — | — | US | disclosed |
| WO-2009102707-A2 | SUBSTITUTED OXAZAPHOSPHORINES | AUSPEX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |
| WO-2009102707-A2 | SUBSTITUTED OXAZAPHOSPHORINES | AUSPEX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |
| US-20090202540-A1 | SUBSTITUTED OXAZAPHOSPHORINES | AUSPEX PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | US | disclosed |
| US-20090202540-A1 | SUBSTITUTED OXAZAPHOSPHORINES | AUSPEX PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | US | disclosed |
| US-20090202540-A1 | SUBSTITUTED OXAZAPHOSPHORINES | AUSPEX PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090202540-A1 | SUBSTITUTED OXAZAPHOSPHORINES | TYMP, PAICS, CD47 | LMNA 4742/4885CYP3A4 2346/4885CHRM2 4471/4885 |
| US-20120095216-A1 | 3-[1,4]OXAZEPANE-4-PYRIMIDONE DERIVATIVES | PSEN1, MAPT, PSEN2 | LMNA 4551/4885CYP3A4 3616/4885CHRM2 732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.