Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 3/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21174649 | 1.00 | DPP7 (0.34) | DPP7DPP4MMP1MMP2MMP8 | |
| SCHEMBL21448827 | 0.78 | DPP7 (0.36) | DPP7DPP4MMP1MMP2MMP8 | |
| SCHEMBL18270916 | 0.78 | DPP7 (0.36) | DPP7DPP4MMP1MMP2MMP8 | |
| SCHEMBL10219753 | 0.71 | DPP4 (0.51) | DPP7DPP4MEN1CYP1A2CYP3A4 | |
| SCHEMBL28614556 | 0.69 | L3MBTL1 (0.43) | DPP7DPP4MMP1MMP2MMP8 | |
| SCHEMBL28614554 | 0.69 | L3MBTL1 (0.43) | DPP7DPP4MMP1MMP2MMP8 | |
| SCHEMBL24141588 | 0.67 | MEN1 (0.38) | DPP7DPP4MMP1MMP2MMP8 | |
| SCHEMBL24141384 | 0.66 | MEN1 (0.40) | DPP7DPP4MMP1MMP2MMP8 | |
| SCHEMBL31336573 | 0.66 | HPGD (0.39) | DPP4MEN1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL23868501 | 0.66 | ALDH1A1 (0.38) | MEN1CYP1A2CYP3A4CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3514158-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | Aptinyx Inc. (US) | 2019-07-24 | — | — | EP | disclosed |