Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | WNT1 | P04628 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.30 |
| ▸ | GCK | P35557 | 2/20 | 0.30 |
| ▸ | RARA | P10276 | 1/20 | 0.30 |
| ▸ | RARB | P10826 | 1/20 | 0.30 |
| ▸ | RARG | P13631 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211922 | 1.00 | PIN1 (0.40) | PIN1NOTUMDYRK1AGSK3BWNT1 | |
| SCHEMBL2840927 | 0.99 | PIN1 (0.40) | PIN1NOTUMDYRK1AGSK3BWNT1 | |
| SCHEMBL213747 | 0.99 | PIN1 (0.40) | PIN1NOTUMDYRK1AGSK3BWNT1 | |
| SCHEMBL212113 | 0.99 | PIN1 (0.40) | PIN1NOTUMDYRK1AGSK3BWNT1 | |
| SCHEMBL209908 | 0.99 | PIN1 (0.40) | PIN1NOTUMDYRK1AGSK3BWNT1 | |
| SCHEMBL2840914 | 0.94 | PIN1 (0.34) | PIN1NOTUMDYRK1AGSK3BWNT1 | |
| SCHEMBL4348511 | 0.94 | PIN1 (0.34) | PIN1NOTUMDYRK1AGSK3BWNT1 | |
| SCHEMBL211785 | 0.94 | PIN1 (0.36) | PIN1DYRK1AGSK3BWNT1MET | |
| SCHEMBL2724097 | 0.94 | PIN1 (0.36) | PIN1DYRK1AGSK3BWNT1MET | |
| SCHEMBL212784 | 0.93 | PIN1 (0.34) | PIN1NOTUMDYRK1AGSK3BWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |