Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 5/20 | 0.34 |
| ▸ | WDR48 | Q8TAF3 | 5/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21190032 | 0.83 | MAPK8 (0.38) | TGFBR1USP2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL21177489 | 0.82 | SCN9A (0.35) | TGFBR1MEN1KMT2AUSP2CYP1A2 | |
| SCHEMBL21177269 | 0.82 | HDAC1 (0.34) | TGFBR1MEN1KMT2AUSP2CYP1A2 | |
| SCHEMBL21190142 | 0.82 | ROCK2 (0.42) | ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL21189975 | 0.82 | ROCK2 (0.40) | ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL21189982 | 0.82 | CYP3A4 (0.43) | MEN1KMT2AUSP2CYP1A2CYP3A4 | |
| SCHEMBL21190173 | 0.82 | ROCK1 (0.43) | ROCK2ROCK1CDC42BPACDC42BPB | |
| Hydrochloric Acid SCHEMBL21177477 | 0.82 | SCN9A (0.35) | TGFBR1MEN1KMT2AUSP2CYP1A2 | |
| SCHEMBL21190037 | 0.82 | CCNT1 (0.31) | USP1WDR48TGFBR1TGFBR2ROCK2 | |
| SCHEMBL21179409 | 0.80 | TGFBR1 (0.46) | TGFBR1TGFBR2ROCK2ROCK1CDC42BPB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200171030-A1 | DUAL INHIBITORS OF ALK5 AND P38A MAP KINASE | INTEGRAL BIOSCIENCES PRIVATE LTD (IN) | 2020-06-04 | — | — | US | disclosed |
| WO-2019142128-A1 | DUAL INHIBITORS OF ALK5 AND P38Α MAP KINASE | INTEGRAL BIOSCIENCES PRIVATE LIMITED (IN) | 2019-07-25 | — | — | WO | disclosed |
| WO-2019142128-A1 | DUAL INHIBITORS OF ALK5 AND P38Α MAP KINASE | INTEGRAL BIOSCIENCES PRIVATE LIMITED (IN) | 2019-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200171030-A1 | DUAL INHIBITORS OF ALK5 AND P38A MAP KINASE | MAP2K2, MAP2K5, MAP2K1 | USP1 3883/4885WDR48 4682/4885TGFBR1 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.