Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2118113 | 0.96 | MAPT (0.54) | PGRKEAP1CYP2C9L3MBTL1NPSR1 | |
| SCHEMBL2121835 | 0.91 | STAT3 (0.52) | PGRKEAP1CYP2C9L3MBTL1NFE2L2 | |
| SCHEMBL2120177 | 0.87 | PGR (0.48) | PGRKEAP1CYP2C9L3MBTL1NFE2L2 | |
| SCHEMBL2117901 | 0.87 | PGR (0.48) | PGRKEAP1CYP2C9L3MBTL1NFE2L2 | |
| SCHEMBL2120655 | 0.86 | PGR (0.46) | PGRKEAP1CYP2C9L3MBTL1NFE2L2 | |
| SCHEMBL2121852 | 0.86 | PGR (0.46) | PGRKEAP1CYP2C9L3MBTL1NFE2L2 | |
| SCHEMBL2120055 | 0.82 | PGR (0.51) | PGRKEAP1CYP2C9L3MBTL1NPSR1 | |
| SCHEMBL2120190 | 0.82 | PGR (0.51) | PGRKEAP1CYP2C9L3MBTL1NPSR1 | |
| SCHEMBL5622356 | 0.81 | PGR (0.79) | PGRKEAP1L3MBTL1NFE2L2MCOLN3 | |
| SCHEMBL2119835 | 0.80 | PGR (0.46) | PGRKEAP1CYP2C9L3MBTL1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095024-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE | ELARA PHARMACEUTICALS GMBH (DE) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095024-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE | HIF1AN, HIF1A, EGLN2 | PGR 2683/4885KEAP1 453/4885CYP2C9 3693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.