Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21178453 | 0.94 | PIK3CD (0.45) | PIK3CDPIK3CGPIK3R1PIK3CALMNA | |
| SCHEMBL21178492 | 0.90 | NPSR1 (0.38) | PIK3CDPIK3CGPIK3R1PIK3CALMNA | |
| SCHEMBL16584903 | 0.86 | ALDH1A1 (0.39) | PIK3CDPIK3CGLMNATSHRNPSR1 | |
| SCHEMBL21178215 | 0.84 | PIK3CD (0.37) | PIK3CDPIK3CGPIK3R1PIK3CALMNA | |
| SCHEMBL21178476 | 0.84 | POLB (0.38) | PIK3CDPIK3CGPIK3R1PIK3CALMNA | |
| SCHEMBL16584875 | 0.83 | SMN1; SMN2 (0.41) | PIK3CDLMNATSHRNPSR1POLB | |
| SCHEMBL21185257 | 0.83 | PIK3CD (0.48) | PIK3CDPIK3CGPIK3R1PIK3CALMNA | |
| SCHEMBL21178507 | 0.83 | PIK3CD (0.45) | PIK3CDPIK3CGPIK3R1PIK3CALMNA | |
| SCHEMBL16584901 | 0.82 | ALDH1A1 (0.39) | PIK3CDLMNATSHRNPSR1POLB | |
| SCHEMBL21185262 | 0.81 | PIK3CD (0.49) | PIK3CDPIK3CGPIK3R1PIK3CAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3740468-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Sunshine Lake Pharma Co., Ltd. (CN) | 2020-11-25 | — | — | EP | disclosed |
| WO-2019143874-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2019-07-25 | — | — | WO | disclosed |