Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18076637 | 0.94 | PIK3CD (0.42) | PIK3CDTP53CASRTRPA1MAPT | |
| SCHEMBL16584901 | 0.88 | ALDH1A1 (0.39) | PIK3CDLMNATSHRNPSR1MTNR1A | |
| SCHEMBL16584903 | 0.88 | ALDH1A1 (0.39) | PIK3CDLMNATSHRNPSR1MTNR1A | |
| SCHEMBL21178492 | 0.86 | NPSR1 (0.38) | SMN1; SMN2PIK3CDLMNATSHRNPSR1 | |
| SCHEMBL18076647 | 0.84 | TSHR (0.51) | SMN1; SMN2LMNATSHRNPSR1POLB | |
| SCHEMBL21178494 | 0.83 | PIK3CD (0.44) | PIK3CDLMNATSHRNPSR1TP53 | |
| SCHEMBL16597161 | 0.82 | ALDH1A1 (0.48) | SMN1; SMN2PIK3CDLMNANPSR1HTR1A | |
| SCHEMBL18076641 | 0.82 | PIK3CD (0.39) | PIK3CDTP53MAPTPOLBHRH3 | |
| SCHEMBL16584926 | 0.82 | PIK3CD (0.40) | PIK3CDTP53POLBHRH3 | |
| SCHEMBL16584911 | 0.81 | PIK3CD (0.42) | SMN1; SMN2PIK3CDLMNANPSR1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3046563-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Calitor Sciences, LLC (US) | 2016-07-27 | — | — | EP | disclosed |
| WO-2015042077-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-03-26 | — | — | WO | disclosed |