SCHEMBL21183115

SCHEMBL21183115

C=CC(=O)Oc1ccc2cc(-c3ccc(OC(O)C=C)cc3)c(=O)oc2c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 9/20 0.54
NPC1 O15118 8/20 0.54
MEN1 O00255 5/20 0.54
KMT2A Q03164 5/20 0.54
KDM4E B2RXH2 3/20 0.54
GLA P06280 3/20 0.54
RXFP1 Q9HBX9 2/20 0.53
POLB P06746 3/20 0.49
CASP3 P42574 1/20 0.49
SENP8 Q96LD8 1/20 0.49
SENP7 Q9BQF6 1/20 0.49
SENP6 Q9GZR1 1/20 0.49
KLK7 P49862 1/20 0.49
MIF P14174 3/20 0.47
SIRT3 Q9NTG7 1/20 0.47
ERAP1 Q9NZ08 1/20 0.47
GAPDH P04406 1/20 0.47
ESR2 Q92731 1/20 0.45
ALDH1A1 P00352 2/20 0.43
GAA P10253 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21663447 0.97 RXFP1 (0.54) RAB9ANPC1MEN1KMT2AKDM4E
SCHEMBL9607852 0.88 RAB9A (0.63) RAB9ANPC1MEN1KMT2AKDM4E
SCHEMBL21587890 0.84 NPC1 (0.61) RAB9ANPC1MEN1KMT2AKDM4E
SCHEMBL9607851 0.84 NPC1 (0.67) RAB9ANPC1MEN1KMT2AKDM4E
SCHEMBL20355398 0.83 NPC1 (0.74) RAB9ANPC1MEN1KMT2AKDM4E
SCHEMBL19497594 0.83 RAB9A (0.57) RAB9ANPC1MEN1KMT2AKDM4E
SCHEMBL20052531 0.83 NPC1 (0.74) RAB9ANPC1MEN1KMT2AKDM4E
SCHEMBL21091107 0.81 NPC1 (0.67) RAB9ANPC1MEN1KMT2AKDM4E
SCHEMBL23543250 0.79 PTPN7 (0.44) RAB9ANPC1MEN1KMT2AKDM4E
SCHEMBL20998363 0.78 THRB (0.42) MEN1KMT2AKDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3112440-B1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2019-07-24 EP disclosed