Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | LTK | P29376 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26347355 | 0.85 | KDM4E (0.38) | ADORA2AKDM4EBCDIN3DALDH1A1GAA | |
| SCHEMBL4841951 | 0.83 | DHFR (0.36) | DYRK1AKDM4EDAPK3PRKD3MAP4K4 | |
| SCHEMBL18640882 | 0.82 | DYRK1A (0.35) | DYRK1AADORA2AADORA1LMNAHTT | |
| SCHEMBL28713842 | 0.79 | ADORA1 (0.34) | DYRK1AADORA2AADORA1TLR7 | |
| SCHEMBL23287642 | 0.75 | PIK3CD (0.40) | MAP4K4KDRMAP2K2CSNK1A1MAP2K1 | |
| SCHEMBL28759411 | 0.74 | PDE10A (0.45) | PDE10ACA12CA2CA9 | |
| SCHEMBL8142879 | 0.73 | HRH4 (0.37) | DYRK1AKDM4EDAPK3PRKD3MAP4K4 | |
| SCHEMBL11221750 | 0.72 | PLK4 (0.35) | DYRK1AKDM4EPRKACAKDRMAPK8 | |
| SCHEMBL7312745 | 0.71 | HPGD (0.45) | ADORA1MAP4K4CLK4ALDH1A1LMNA | |
| SCHEMBL20583747 | 0.71 | ADORA2A (0.39) | DYRK1AADORA2AADORA1KDM4EDAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3513793-A1 | HETEROCYCLYLAMINES AS PI3K INHIBITORS | Incyte Holdings Corporation (US) | 2019-07-24 | — | — | EP | disclosed |