Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | UBE2N | P61088 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316090 | 0.78 | HPGD (0.38) | HPGDCSNK1D | |
| SCHEMBL7316083 | 0.77 | KDM4E (0.46) | HPGDALDH1A1HSD17B10 | |
| SCHEMBL7313398 | 0.75 | POLB (0.42) | HPGDALDH1A1MAPK1CLK1UBE2N | |
| SCHEMBL7319490 | 0.74 | MEN1 (0.46) | HPGDALDH1A1CSNK1DGSK3B | |
| SCHEMBL7308816 | 0.73 | KDR (0.39) | HPGDALDH1A1HSD17B10 | |
| SCHEMBL21183232 | 0.71 | DYRK1A (0.38) | ALDH1A1MAP4K4CLK4ADORA1LMNA | |
| SCHEMBL4841951 | 0.71 | DHFR (0.36) | ALDH1A1MAP4K4CLK4LMNA | |
| SCHEMBL20295395 | 0.71 | KDM4E (0.40) | HPGDALDH1A1MAPK1CLK1UBE2N | |
| SCHEMBL7312345 | 0.70 | PDE3B (0.38) | HRH4CDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL11006461 | 0.68 | MAPT (0.46) | HPGDALDH1A1MAPK1HSD17B10HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541187-A | HYPOTENSIVE AGENTS | STERLING WINTHROP INC. (US) | 1996-07-30 | — | — | US | disclosed |
| US-5294612-A | Hypotensive agents and cardiovascular disorders | STERLING WINTHROP INC. (US) | 1994-03-15 | — | — | US | disclosed |