Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.67 |
| ▸ | BRD2 | P25440 | 4/20 | 0.67 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.67 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | IDH1 | O75874 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21183365 | 0.81 | TP53 (0.72) | BRD4BRD2BRD3KMT2AMEN1 | |
| SCHEMBL793716 | 0.81 | LMNA (0.61) | BRD4BRD2BRD3MAPTPOLB | |
| SCHEMBL21183368 | 0.78 | BRD4 (0.61) | BRD4BRD2BRD3MAPTPOLB | |
| SCHEMBL21183373 | 0.76 | MAPT (0.61) | BRD4BRD2BRD3KMT2AMEN1 | |
| SCHEMBL22566366 | 0.74 | BRD4 (0.57) | BRD4BRD2BRD3KMT2AMEN1 | |
| SCHEMBL14363634 | 0.74 | L3MBTL1 (0.77) | KMT2AMEN1MAPTPKMTP53 | |
| SCHEMBL15647514 | 0.74 | KMT2A (0.75) | BRD4BRD2BRD3KMT2AMEN1 | |
| SCHEMBL15646419 | 0.70 | MEN1 (0.67) | BRD4BRD2BRD3KMT2AMEN1 | |
| SCHEMBL14645519 | 0.70 | HDAC4 (1.00) | HDAC4HDAC1HDAC6KMT2AMEN1 | |
| SCHEMBL12112407 | 0.68 | NPC1 (0.61) | KMT2AMEN1MAPTPKMTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019142191-A1 | NEW METHIONINE METABOLIC PATHWAY INHIBITORS | GAVISH-GALILEE BIO APPLICATIONS LTD. (IL) | 2019-07-25 | — | — | WO | disclosed |