Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 11/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.41 |
| ▸ | EGFR | P00533 | 6/20 | 0.41 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2113935 | 0.85 | LRRK2 (0.42) | FLT3ABL1RETALKKDR | |
| SCHEMBL2114389 | 0.85 | FLT3 (0.41) | FLT3ABL1RETALKKDR | |
| SCHEMBL2113982 | 0.84 | KDR (0.47) | FLT3KDRPDGFRBFGFR1EGFR | |
| SCHEMBL2116233 | 0.82 | FLT3 (0.41) | FLT3ABL1RETALKKDR | |
| SCHEMBL2118752 | 0.79 | KDR (0.46) | FLT3ABL1RETALKKDR | |
| SCHEMBL2115933 | 0.79 | KDR (0.44) | FLT3KDRPDGFRBFGFR1EGFR | |
| SCHEMBL2116290 | 0.78 | LRRK2 (0.41) | FLT3ABL1RETALKKDR | |
| SCHEMBL2114117 | 0.76 | KDR (0.46) | FLT3KDRPDGFRBFGFR1EGFR | |
| SCHEMBL2116213 | 0.75 | FGFR1 (0.51) | FLT3KDRPDGFRBFGFR1EGFR | |
| SCHEMBL31672465 | 0.74 | KDR (0.60) | FLT3ABL1RETALKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | NEKTAR THERAPEUTICS (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | PTK2B, ERBB2, FRK | FLT3 111/4885ABL1 28/4885RET 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.