SCHEMBL21185018

SCHEMBL21185018

Cc1c(F)ccc2c1CSc1ccccc1[C@H]2C

nearest known ligand 0.34

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.34
MAPT P10636 1/20 0.34
HPGD P15428 1/20 0.34
ALOX12 P18054 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
TAS1R3 Q7RTX0 1/20 0.33
TAS1R1 Q7RTX1 1/20 0.33
TAS1R2 Q8TE23 1/20 0.33
GAA P10253 1/20 0.33
TAAR1 Q96RJ0 2/20 0.31
CYP2D6 P10635 1/20 0.31
ABCB11 O95342 1/20 0.31
OPRM1 P35372 1/20 0.31
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20108777 0.87 ABCB11 (0.39) ALDH1A1MAPTHPGDALOX12TDP1
SCHEMBL23605202 0.87 ABCB11 (0.39) ALDH1A1MAPTHPGDALOX12TDP1
SCHEMBL16385911 0.86 ALDH1A1 (0.36) ALDH1A1MAPTHPGDALOX12TDP1
SCHEMBL25922866 0.86 ALDH1A1 (0.36) ALDH1A1MAPTHPGDALOX12TDP1
SCHEMBL22508301 0.84 ALDH1A1 (0.38) ALDH1A1MAPTHPGDALOX12TDP1
SCHEMBL12997783 0.84 ALDH1A1 (0.33) ALDH1A1MAPTHPGDALOX12TDP1
SCHEMBL21185263 0.82 ALDH1A1 (0.35) ALDH1A1MAPTHPGDALOX12TDP1
SCHEMBL12997784 0.81 PIM1 (0.33) ALDH1A1MAPTHPGDALOX12TDP1
SCHEMBL16385864 0.78 NPC1 (0.36) ALDH1A1MAPTHPGDALOX12TDP1
SCHEMBL12997704 0.77 NPC1 (0.39) ALDH1A1MAPTHPGDALOX12TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019141179-A1 PYRIDONE DERIVATIVE, COMPOSITION THEREOF AND APPLICATION THEREOF AS ANTI-INFLUENZA DRUG 银杏树药业(苏州)有限公司 2019-07-25 WO disclosed