Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.50 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21185368 | 0.85 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3CAPIK3R1KCNH2 | |
| SCHEMBL21185363 | 0.84 | PIK3CD (0.50) | PIK3CDPIK3CGPIK3CAPIK3R1KCNH2 | |
| SCHEMBL21174775 | 0.83 | PIK3CD (0.56) | PIK3CDPIK3CGPIK3CAPIK3R1KCNH2 | |
| SCHEMBL21174772 | 0.83 | PIK3CD (0.56) | PIK3CDPIK3CGPIK3CAPIK3R1KCNH2 | |
| SCHEMBL20247392 | 0.82 | ALDH1A1 (0.47) | PIK3CDPIK3CGPIK3R1KCNH2ALDH1A1 | |
| SCHEMBL21185366 | 0.82 | PIK3CD (0.48) | PIK3CDPIK3CGPIK3CAPIK3R1KCNH2 | |
| SCHEMBL23678125 | 0.80 | PIK3CG (0.49) | PIK3CDPIK3CGPIK3CAPIK3R1PIK3CB | |
| SCHEMBL19863998 | 0.79 | PIK3CD (0.50) | PIK3CDPIK3CGPIK3CAPIK3R1KCNH2 | |
| SCHEMBL24731225 | 0.78 | PIK3CD (0.51) | PIK3CDPIK3CGPIK3CAPIK3R1ALDH1A1 | |
| SCHEMBL16597185 | 0.78 | PDE10A (0.52) | PIK3CDPIK3CGPIK3CAPIK3R1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143874-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2019-07-25 | — | — | WO | disclosed |