Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24731282 | 0.89 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CBPIK3CGSMN1; SMN2 | |
| SCHEMBL20247392 | 0.88 | ALDH1A1 (0.47) | PIK3CDPIK3CBPIK3CGSMN1; SMN2ALDH1A1 | |
| SCHEMBL21185368 | 0.86 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CBPIK3CGSMN1; SMN2 | |
| SCHEMBL21185363 | 0.86 | PIK3CD (0.50) | PIK3CDPIK3CAPIK3CBPIK3CGSMN1; SMN2 | |
| SCHEMBL24731226 | 0.84 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CBPIK3CGSMN1; SMN2 | |
| SCHEMBL16597185 | 0.83 | PDE10A (0.52) | PIK3CDPIK3CAPIK3CBPIK3CGSMN1; SMN2 | |
| SCHEMBL21178426 | 0.83 | PIK3CD (0.48) | PIK3CDPIK3CAPIK3CBPIK3CGSMN1; SMN2 | |
| SCHEMBL20404396 | 0.83 | PIK3CD (0.57) | PIK3CDPIK3CGSMN1; SMN2ALDH1A1ESR1 | |
| SCHEMBL19135929 | 0.82 | CYP1A2 (0.39) | SMN1; SMN2ALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL21185241 | 0.82 | PIK3CD (0.50) | PIK3CDPIK3CAPIK3CBPIK3CGSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143874-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2019-07-25 | — | — | WO | disclosed |