SCHEMBL21186206

SCHEMBL21186206

CN(c1ccc(N)cc1)c1ccc(F)cc1Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 5/20 0.39
ALDH1A1 P00352 2/20 0.39
MAPK1 P28482 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
TP53 P04637 1/20 0.39
ALOX15 P16050 1/20 0.39
DHFR P00374 1/20 0.35
TAAR1 Q96RJ0 1/20 0.33
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33
SLC6A3 Q01959 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
GAA P10253 1/20 0.33
KMT2A Q03164 1/20 0.33
TSHR P16473 2/20 0.32
L3MBTL1 Q9Y468 2/20 0.32
PSMD14 O00487 1/20 0.32
RECQL P46063 1/20 0.32
GFER P55789 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22453194 0.83 FSCN1 (0.46) CYP3A4ALDH1A1MAPK1TDP1TP53
SCHEMBL28123829 0.76 CYP3A4 (0.33) CYP3A4TAAR1CYP2C9CYP2C19KDM4E
SCHEMBL6811930 0.76 CYP3A4 (0.51) CYP3A4ALDH1A1TDP1ALOX15CYP2C9
SCHEMBL23720055 0.75 CYP3A4 (0.45) CYP3A4ALDH1A1MAPK1TDP1TP53
SCHEMBL21185998 0.74 AXL (0.57) CYP3A4CYP2C19GAAL3MBTL1GFER
SCHEMBL13338133 0.71 MAPK14 (0.41) CYP3A4ALDH1A1DHFRTAAR1KMT2A
SCHEMBL19433340 0.70 DHFR (0.38) CYP3A4ALDH1A1TP53DHFRGAA
SCHEMBL31135775 0.70 DHFR (0.38) CYP3A4ALDH1A1TP53DHFRGAA
SCHEMBL21129714 0.69 HTT (0.34) CYP3A4MAPK1ALOX15SLC6A2SLC6A4
SCHEMBL21474106 0.69 ALDH1A1 (0.68) CYP3A4ALDH1A1MAPK1TDP1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019141980-A1 AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2019-07-25 WO disclosed