SCHEMBL21186388

SCHEMBL21186388

Nc1nc2cccc(Oc3ccccc3)c2s1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.51
RAB9A P51151 2/20 0.51
MAPT P10636 2/20 0.51
HTT P42858 2/20 0.51
TP53 P04637 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
KDM4E B2RXH2 1/20 0.40
GLA P06280 1/20 0.40
KMT2A Q03164 1/20 0.40
ASH1L Q9NR48 1/20 0.39
DPP4 P27487 1/20 0.38
KDM1A O60341 1/20 0.38
CXCR2 P25025 1/20 0.38
CYP3A4 P08684 2/20 0.38
TDP1 Q9NUW8 1/20 0.37
PIK3CA P42336 1/20 0.37
PI4KA P42356 1/20 0.37
PI4KB Q9UBF8 1/20 0.37
MAOB P27338 1/20 0.37
HRH1 P35367 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL84829 0.80 CYP3A4 (0.57) NPC1RAB9AMAPTKDM4EKMT2A
SCHEMBL30967515 0.74 ALDH1A1 (0.48) NPC1MAPTHTTTP53KDM4E
SCHEMBL1018687 0.74 F2RL3 (0.40) NPC1RAB9AMAPTHTTTP53
SCHEMBL28199955 0.74 ASH1L (0.39) NPC1RAB9AMAPTHTTTP53
SCHEMBL11109898 0.74 TDP1 (0.64) NPC1RAB9AMAPTHTTTP53
SCHEMBL1420071 0.74 SCN9A (0.48) NPC1RAB9AMAPTTP53SMN1; SMN2
SCHEMBL3046443 0.74 CYP3A4 (0.51) NPC1RAB9AMAPTHTTTP53
SCHEMBL30967498 0.72 TLR8 (0.49) NPC1RAB9AMAPTTP53SMN1; SMN2
SCHEMBL1619718 0.72 ASH1L (0.44) NPC1RAB9AMAPTHTTTP53
SCHEMBL14860945 0.71 ASH1L (0.62) NPC1RAB9AMAPTKDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019141980-A1 AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2019-07-25 WO disclosed