Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.58 |
| ▸ | KMO | O15229 | 7/20 | 0.48 |
| ▸ | RARA | P10276 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | RARG | P13631 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | RPA1 | P27694 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2118385 | 0.83 | TRPV1 (0.45) | TRPV1KMORARARARBRARG | |
| SCHEMBL2117773 | 0.81 | TRPV1 (0.55) | TRPV1 | |
| SCHEMBL1686339 | 0.78 | TRPV1 (0.56) | TRPV1KMORARARARBRARG | |
| SCHEMBL10068661 | 0.76 | TRPV1 (0.71) | TRPV1PDE4APDE4BPDE4CCNR2 | |
| SCHEMBL2118735 | 0.76 | TRPV1 (0.71) | TRPV1PDE4APDE4BPDE4CCNR2 | |
| SCHEMBL2118730 | 0.76 | TRPV1 (0.71) | TRPV1PDE4APDE4BPDE4CCNR2 | |
| SCHEMBL2118737 | 0.76 | TRPV1 (0.71) | TRPV1PDE4APDE4BPDE4CCNR2 | |
| SCHEMBL2117764 | 0.75 | TRPV1 (1.00) | TRPV1 | |
| SCHEMBL2120590 | 0.75 | TRPV1 (0.58) | TRPV1 | |
| SCHEMBL11902319 | 0.75 | PTPN1 (0.60) | KMORARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095002-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2012-04-19 | — | — | US | disclosed |
| EP-2393788-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. Organon (NL) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089297-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2010-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095002-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | TRPV1, TRPV5, P2RX5 | TRPV1 1/4885KMO 1098/4885RARA 2663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.