Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.57 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.57 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.57 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.57 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.57 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.57 |
| ▸ | CCR9 | P51686 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2120014 | 0.88 | POLB (0.51) | POLBCYP3A4CYP2D6PSEN1PSEN2 | |
| SCHEMBL2121436 | 0.88 | POLB (0.51) | POLBCYP3A4CYP2D6PSEN1PSEN2 | |
| SCHEMBL2119292 | 0.85 | CCR9 (0.48) | POLBCYP3A4CYP2D6PSEN1PSEN2 | |
| SCHEMBL2119257 | 0.83 | POLB (0.48) | POLBCYP3A4CYP2D6PSEN1PSEN2 | |
| SCHEMBL2118524 | 0.82 | TRIM24 (0.57) | POLBCYP3A4MAPTTP53SMN1; SMN2 | |
| SCHEMBL2121588 | 0.81 | CYP3A4 (0.46) | POLBCYP3A4CYP2D6PSEN1PSEN2 | |
| SCHEMBL2119449 | 0.81 | CYP3A4 (0.46) | POLBCYP3A4CYP2D6PSEN1PSEN2 | |
| SCHEMBL2117458 | 0.81 | POLB (0.54) | POLBMAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL2117617 | 0.81 | CYP3A4 (0.46) | POLBCYP3A4CYP2D6PSEN1PSEN2 | |
| SCHEMBL2118369 | 0.80 | ALDH1A1 (0.56) | POLBCYP3A4CYP2D6PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095024-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE | ELARA PHARMACEUTICALS GMBH (DE) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095024-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE | HIF1AN, HIF1A, EGLN2 | POLB 817/4885CYP3A4 3761/4885CYP2D6 4129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.