Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17730029 | 0.81 | LMNA (0.70) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL17730073 | 0.81 | LMNA (0.70) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL21187086 | 0.81 | MEN1 (0.49) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL4911807 | 0.81 | LMNA (0.70) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL21187084 | 0.81 | MEN1 (0.49) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL21187213 | 0.76 | NPC1 (0.48) | MEN1KMT2ANPC1RAB9AEPHX2 | |
| SCHEMBL21187117 | 0.74 | IDO1 (0.51) | CYP3A4CYP2C19 | |
| SCHEMBL21187139 | 0.74 | NPC1 (0.45) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL21187111 | 0.74 | NPC1 (0.45) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL21187193 | 0.72 | THRB (0.38) | NPC1RAB9AEPHX2EPHX1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019141095-A1 | AMIDINE AND GUANIDINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2019-07-25 | — | — | WO | disclosed |