Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | CCR1 | P32246 | 2/20 | 0.36 |
| ▸ | CCR5 | P51681 | 2/20 | 0.36 |
| ▸ | CCR8 | P51685 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.34 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.33 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13801171 | 0.82 | UHRF1 (0.48) | UHRF1CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL3449694 | 0.76 | UHRF1 (0.46) | UHRF1DYRK1ACYP2D6PSEN1PSEN2 | |
| SCHEMBL14317797 | 0.76 | CA1 (0.46) | UHRF1LRRK2 | |
| SCHEMBL3466579 | 0.76 | UHRF1 (0.46) | UHRF1CCR1CCR5CCR8CYP2D6 | |
| SCHEMBL30410070 | 0.76 | UHRF1 (0.46) | UHRF1DYRK1ACYP2D6PSEN1PSEN2 | |
| SCHEMBL18752478 | 0.74 | UHRF1 (0.45) | UHRF1DYRK1ACCR1CCR5CCR8 | |
| SCHEMBL26308907 | 0.74 | UHRF1 (0.45) | UHRF1CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL25463208 | 0.73 | LMNA (0.50) | UHRF1CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL16139759 | 0.69 | ALDH1A1 (0.53) | KDM4EMEN1KMT2A | |
| SCHEMBL1896511 | 0.69 | DYRK1A (0.65) | UHRF1DYRK1ACYP2D6PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019141095-A1 | AMIDINE AND GUANIDINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2019-07-25 | — | — | WO | disclosed |