Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 10/20 | 0.44 |
| ▸ | SRC | P12931 | 4/20 | 0.40 |
| ▸ | LCK | P06239 | 3/20 | 0.40 |
| ▸ | CFTR | P13569 | 2/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 6/20 | 0.38 |
| ▸ | TEK | Q02763 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | YES1 | P07947 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | HCK | P08631 | 1/20 | 0.38 |
| ▸ | FGR | P09769 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23481428 | 0.83 | EIF2AK3 (0.41) | EIF2AK3SRCLCKCFTRRIPK1 | |
| SCHEMBL20173316 | 0.82 | PIK3CD (0.45) | EIF2AK3SRCLCKCFTRABL1 | |
| SCHEMBL20173312 | 0.82 | SRC (0.43) | EIF2AK3SRCLCKCFTRABL1 | |
| SCHEMBL20173310 | 0.82 | CFTR (0.43) | EIF2AK3SRCLCKCFTRTEK | |
| SCHEMBL20173313 | 0.82 | CFTR (0.41) | EIF2AK3SRCLCKCFTRTEK | |
| SCHEMBL30037245 | 0.81 | CFTR (0.41) | EIF2AK3SRCLCKCFTRRIPK1 | |
| SCHEMBL20162676 | 0.81 | CFTR (0.41) | EIF2AK3SRCLCKCFTRRIPK1 | |
| SCHEMBL20181897 | 0.81 | SRC (0.42) | EIF2AK3SRCLCKCFTRTEK | |
| SCHEMBL20173320 | 0.81 | SRC (0.43) | EIF2AK3SRCLCKCFTRTEK | |
| SCHEMBL20173321 | 0.81 | SRC (0.52) | SRCLCKTEKABL1ABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190225621-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION | 2019-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190225621-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CFTR, P2RX1, P2RX5 | EIF2AK3 2813/4885SRC 3551/4885LCK 1198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.