Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 16/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | NQO1 | P15559 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21187323 | 0.81 | TTK (0.34) | TTK | |
| SCHEMBL21187279 | 0.74 | PRKDC (0.39) | NQO1 | |
| SCHEMBL21187390 | 0.74 | MAPT (0.35) | NQO1 | |
| SCHEMBL21187388 | 0.71 | FLT3 (0.35) | SYKTTK | |
| SCHEMBL23059584 | 0.61 | — | — | |
| SCHEMBL21187792 | 0.61 | — | — | |
| SCHEMBL21286545 | 0.61 | — | — | |
| SCHEMBL20216508 | 0.61 | — | — | |
| SCHEMBL16038633 | 0.59 | SYK (0.43) | TBK1IKBKESYKLRRK2 | |
| SCHEMBL16040024 | 0.59 | SYK (0.43) | TBK1IKBKESYKLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143678-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-07-25 | — | — | WO | disclosed |