Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PRKDC | P78527 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21187279 | 0.84 | PRKDC (0.39) | MAPTPRKDCKDM4ELMNATSHR | |
| SCHEMBL21187388 | 0.74 | FLT3 (0.35) | MAPTKDM4EMEN1RAB9AKMT2A | |
| SCHEMBL21187323 | 0.74 | TTK (0.34) | MAPTKDM4EMEN1RAB9AKMT2A | |
| SCHEMBL21187280 | 0.74 | TBK1 (0.33) | NQO1 | |
| SCHEMBL21187389 | 0.70 | KDM4E (0.30) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL2124845 | 0.64 | POLB (0.39) | MAPTKDM4ELMNAALDH1A1MEN1 | |
| SCHEMBL28640180 | 0.64 | LMNA (0.61) | MAPTPRKDCKDM4ELMNATSHR | |
| SCHEMBL1686017 | 0.63 | UHRF1 (0.40) | MAPTKDM4ELMNAALDH1A1MEN1 | |
| SCHEMBL24270121 | 0.63 | KDM4E (0.50) | MAPTPRKDCKDM4ELMNATSHR | |
| SCHEMBL7534270 | 0.62 | KDM4E (0.55) | MAPTKDM4ELMNATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143678-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-07-25 | — | — | WO | disclosed |