Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 6/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21187323 | 0.90 | TTK (0.34) | TTKALOX5GAAPIK3CBMAPK8 | |
| SCHEMBL21187279 | 0.74 | PRKDC (0.39) | FLT3PIK3CBMEN1KMT2AMAPT | |
| SCHEMBL21187390 | 0.74 | MAPT (0.35) | FLT3MEN1KMT2AMAPTKDM4E | |
| SCHEMBL21187280 | 0.71 | TBK1 (0.33) | SYKTTK | |
| SCHEMBL16091551 | 0.70 | SYK (0.43) | FLT3SYKHRH4 | |
| SCHEMBL21271405 | 0.70 | SYK (0.43) | FLT3SYKHRH4 | |
| SCHEMBL29578976 | 0.70 | SYK (0.43) | FLT3SYKHRH4 | |
| SCHEMBL25041488 | 0.68 | TTK (0.46) | FLT3SYKTTKGAAMEN1 | |
| SCHEMBL21278966 | 0.65 | TTK (0.43) | SYKTTKALOX5GAAADORA3 | |
| SCHEMBL25039362 | 0.62 | FLT3 (0.48) | FLT3SYKGAAADORA3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143678-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-07-25 | — | — | WO | disclosed |