Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.35 |
| ▸ | SUV39H2 | Q9H5I1 | 3/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | PRKDC | P78527 | 2/20 | 0.34 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | CKS1B | P61024 | 1/20 | 0.32 |
| ▸ | SKP1 | P63208 | 1/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21178579 | 0.86 | RAF1 (0.40) | BTKSUV39H2MAP4K4PRKDCCCRL2 | |
| SCHEMBL21187398 | 0.86 | RAF1 (0.40) | BTKSUV39H2MAP4K4PRKDCCCRL2 | |
| SCHEMBL21187339 | 0.76 | MAP4K4 (0.38) | BTKSUV39H2MAP4K4CCRL2DRD2 | |
| SCHEMBL21178350 | 0.74 | JAK3 (0.41) | BTKSUV39H2MAP4K4CCRL2DRD2 | |
| SCHEMBL21187338 | 0.74 | JAK3 (0.41) | BTKSUV39H2MAP4K4CCRL2DRD2 | |
| SCHEMBL30823290 | 0.73 | PIK3CD (0.40) | PRKDCKCNH2DRD2DRD3MEN1 | |
| SCHEMBL22651983 | 0.73 | PIK3CD (0.40) | PRKDCKCNH2DRD2DRD3MEN1 | |
| SCHEMBL28461575 | 0.73 | PIK3CD (0.40) | PRKDCKCNH2DRD2DRD3MEN1 | |
| SCHEMBL21279209 | 0.70 | CACNB4 (0.39) | BTKSUV39H2MAP4K4DRD2KDM4D | |
| SCHEMBL16079597 | 0.70 | CACNB4 (0.39) | BTKSUV39H2MAP4K4DRD2KDM4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143678-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-07-25 | — | — | WO | disclosed |