Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SIK1 | P57059 | 1/20 | 0.36 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.36 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30823290 | 1.00 | PIK3CD (0.40) | PIK3CDPIK3CAPIK3CBPIK3CGLDHA | |
| SCHEMBL28461575 | 1.00 | PIK3CD (0.40) | PIK3CDPIK3CAPIK3CBPIK3CGLDHA | |
| SCHEMBL21178579 | 0.86 | RAF1 (0.40) | PIK3CDPIK3CAPIK3CBPIK3CGRAF1 | |
| SCHEMBL21187398 | 0.86 | RAF1 (0.40) | PIK3CDPIK3CAPIK3CBPIK3CGRAF1 | |
| SCHEMBL21177923 | 0.86 | PIK3CD (0.42) | PIK3CDPIK3CAPIK3CBPIK3CGLDHA | |
| SCHEMBL21177920 | 0.86 | PIK3CD (0.42) | PIK3CDPIK3CAPIK3CBPIK3CGLDHA | |
| SCHEMBL16079637 | 0.83 | PIK3CD (0.43) | PIK3CDPIK3CAPIK3CBPIK3CGLDHA | |
| SCHEMBL21278974 | 0.83 | PIK3CD (0.43) | PIK3CDPIK3CAPIK3CBPIK3CGLDHA | |
| SCHEMBL21187412 | 0.81 | ALDH1A1 (0.37) | PIK3CDPIK3CAPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL21177871 | 0.81 | SYK (0.47) | RAF1BRAFPRKDCKCNH2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200353101-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2020-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200353101-A1 | DNA-PK INHIBITORS | POLK, DTYMK, DCK | PIK3CD 623/4885PIK3CA 271/4885PIK3CB 496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.