Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 15/20 | 0.65 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2117779 | 0.92 | TRPV1 (0.73) | TRPV1HDAC4NPC1RAB9ATDP1 | |
| SCHEMBL2119809 | 0.84 | TRPV1 (0.56) | TRPV1HDAC4CYP11B1CYP11B2 | |
| SCHEMBL2118817 | 0.83 | TRPV1 (0.58) | TRPV1HDAC4NPC1RAB9ATDP1 | |
| SCHEMBL2118941 | 0.81 | TRPV1 (0.51) | TRPV1HDAC4CYP11B1CYP11B2 | |
| SCHEMBL2119933 | 0.80 | TRPV1 (0.58) | TRPV1HDAC4 | |
| SCHEMBL766448 | 0.78 | TRPV1 (1.00) | TRPV1 | |
| SCHEMBL1686491 | 0.78 | TRPV1 (0.82) | TRPV1 | |
| SCHEMBL766424 | 0.77 | TRPV1 (0.79) | TRPV1 | |
| SCHEMBL766582 | 0.77 | TRPV1 (0.79) | TRPV1 | |
| SCHEMBL2118948 | 0.77 | TRPV1 (0.56) | TRPV1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095002-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095002-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | TRPV1, TRPV5, P2RX5 | TRPV1 1/4885HDAC4 879/4885NPC1 1569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.