Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.44 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 2/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 3/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17875696 | 0.81 | BRD4 (0.44) | BRD4BRD2JAK2MBOAT4TLR8 | |
| SCHEMBL21188508 | 0.77 | BRD4 (0.39) | BRD4BRD2JAK2MBOAT4TLR8 | |
| SCHEMBL18319367 | 0.72 | ERN1 (0.43) | BRD4BRD2JAK2MBOAT4TLR8 | |
| SCHEMBL19296089 | 0.70 | BRD4 (0.44) | BRD4BRD2CYP1A2CYP3A4USP2 | |
| SCHEMBL17875699 | 0.70 | BRD4 (0.40) | BRD4BRD2CYP1A2CYP3A4USP2 | |
| SCHEMBL30522617 | 0.69 | BRD4 (0.46) | BRD4BRD2JAK2TLR8CYP1A2 | |
| SCHEMBL29836739 | 0.69 | BRD4 (0.46) | BRD4BRD2JAK2MBOAT4TLR8 | |
| SCHEMBL14620954 | 0.69 | KDM4E (0.44) | TLR8CYP1A2USP2ALDH1A1KMT2A | |
| SCHEMBL17643820 | 0.69 | BRD4 (0.40) | BRD4BRD2CYP1A2CYP3A4USP2 | |
| SCHEMBL4102764 | 0.68 | TLR8 (0.40) | BRD4BRD2JAK2MBOAT4TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143719-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |