Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 11/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.42 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.37 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 2/20 | 0.34 |
| ▸ | CCNH | P51946 | 2/20 | 0.34 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21188578 | 0.82 | CCNK (0.44) | CLK1CDK5CDK5R1CDK7CCNH | |
| SCHEMBL24839617 | 0.69 | CLK1 (0.49) | CLK1CDK5CDK5R1MAP3K14CDK7 | |
| SCHEMBL21188482 | 0.67 | PDPK1 (0.37) | CLK1CDK5CDK5R1MAP3K14PIKFYVE | |
| SCHEMBL4925137 | 0.65 | DYRK1A (0.57) | CLK1CDK5CDK5R1MAP3K14 | |
| SCHEMBL29488129 | 0.63 | MAP3K14 (0.65) | CLK1CDK5CDK5R1MAP3K14 | |
| SCHEMBL26043640 | 0.62 | CCNK (0.60) | CLK1CDK5CDK5R1CDK7CCNH | |
| SCHEMBL26043638 | 0.62 | CCNK (0.51) | CLK1CDK5CDK5R1CDK7CCNH | |
| SCHEMBL29488124 | 0.61 | CLK1 (0.55) | CLK1CDK5CDK5R1MAP3K14 | |
| SCHEMBL5401708 | 0.59 | DHFR (0.41) | — | |
| SCHEMBL29488127 | 0.59 | CLK1 (0.52) | CLK1CDK5CDK5R1MAP3K14CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143719-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |