Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 3/20 | 0.37 |
| ▸ | CLK1 | P49759 | 11/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 9/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | CDK9 | P50750 | 2/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.31 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.30 |
| ▸ | CDC7 | O00311 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | PRKACA | P17612 | 1/20 | 0.30 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.30 |
| ▸ | CDK8 | P49336 | 1/20 | 0.30 |
| ▸ | CLK2 | P49760 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21188541 | 0.71 | CDK7 (0.32) | PDPK1 | |
| SCHEMBL21188782 | 0.67 | CLK1 (0.43) | CLK1CDK5CDK5R1MAP3K14PIKFYVE | |
| SCHEMBL11994176 | 0.62 | ADORA1 (0.48) | — | |
| SCHEMBL19930866 | 0.62 | CDK5 (0.47) | CDK5CDK5R1 | |
| SCHEMBL2996841 | 0.61 | CDK5 (0.48) | PDPK1CLK1CDK5CDK5R1CCNT1 | |
| SCHEMBL28201697 | 0.59 | PKM (0.56) | — | |
| SCHEMBL21188528 | 0.59 | APP (0.38) | CDK5CDK2ROCK2CDK8CLK2 | |
| SCHEMBL4925137 | 0.59 | DYRK1A (0.57) | PDPK1CLK1CDK5CDK5R1MAP3K14 | |
| SCHEMBL3696797 | 0.58 | ADORA2A (0.52) | — | |
| SCHEMBL2984404 | 0.58 | CDK5 (0.64) | PDPK1CLK1CDK5CDK5R1MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143719-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |