Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | LPL | P06858 | 2/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.34 |
| ▸ | F11 | P03951 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | P4HB | P07237 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21177337 | 0.93 | PDK2 (0.36) | AAK1ALDH1A1LIPGROCK1LPL | |
| SCHEMBL21179344 | 0.86 | HIF1A (0.36) | ALDH1A1LIPGROCK1LPLHIF1A | |
| SCHEMBL22858943 | 0.86 | HIF1A (0.36) | AAK1ALDH1A1LIPGROCK1LPL | |
| SCHEMBL21177390 | 0.86 | TSHR (0.38) | AAK1ALDH1A1LIPGROCK1LPL | |
| SCHEMBL21177403 | 0.83 | CSF1R (0.38) | AAK1LIPGROCK1HIF1ALRRK2 | |
| SCHEMBL24108583 | 0.83 | ALDH1A1 (0.40) | AAK1ALDH1A1LIPGROCK1LPL | |
| SCHEMBL21179433 | 0.80 | HIF1A (0.35) | LIPGROCK1LPLPDK2HIF1A | |
| SCHEMBL22922489 | 0.79 | HDAC4 (0.43) | LIPGLPLPDK2F11CA1 | |
| SCHEMBL18274838 | 0.78 | LPL (0.48) | LIPGLPL | |
| SCHEMBL1721722 | 0.77 | ALDH1A1 (0.47) | AAK1ALDH1A1LIPGROCK1LPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117069728-A | PI4KIII beta inhibitors | 葛兰素史克知识产权开发有限公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-111868063-A | PI4KIII beta inhibitors | 葛兰素史克知识产权开发有限公司 | 2020-10-30 | — | — | CN | disclosed |
| WO-2019141694-A1 | PI4KIIIBETA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-07-25 | — | — | WO | disclosed |