Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 8/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.31 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30977616 | 0.72 | KDM4E (0.43) | KDM4ENPC1ALDH1A1RAB9AKDM5B | |
| SCHEMBL21190756 | 0.70 | BRD4 (1.00) | BRD4 | |
| SCHEMBL21190833 | 0.64 | ALDH1A1 (0.41) | BRD4KDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL31034942 | 0.64 | ALDH1A1 (0.38) | BRD4KDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL21190842 | 0.62 | BRD4 (0.50) | BRD4ALDH1A1 | |
| SCHEMBL21190868 | 0.61 | BRD4 (0.53) | BRD4ALDH1A1HSD17B10 | |
| SCHEMBL22346797 | 0.60 | KDM4E (0.41) | KDM4ENPC1ALDH1A1RAB9AKDM5B | |
| SCHEMBL30947037 | 0.58 | HTT (0.41) | KDM4ENPC1ALDH1A1RAB9ALMNA | |
| SCHEMBL24375318 | 0.57 | KDM4E (0.44) | KDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL31309282 | 0.57 | KDM4E (0.45) | KDM4ENPC1ALDH1A1RAB9AGRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3741758-A1 | BROMODOMAIN INHIBITOR COMPOUND AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2020-11-25 | — | — | EP | disclosed |
| WO-2019141131-A1 | BROMODOMAIN INHIBITOR COMPOUND AND USE THEREOF | 中国科学院上海药物研究所 | 2019-07-25 | — | — | WO | disclosed |
| US-9359548-B2 | Organic electroluminescent device | UDC IRELAND LIMITED (IE) | 2016-06-07 | — | — | US | disclosed |